Francosko-kanadska policija v Montrealu pokliče posebnega agenta FBI-ja Illeana Scotta (Angelina Jolie), specializiranega za psihološko profiliranje, da poskuša ujeti serijskega morilca, za katerega se zdi, da domneva identiteto svojih žrtev. Pri preiskavi pomaga pojav Jamesa Costa (Ethan Hawke), priče, ki je morilca videl prav tak, kot je bil z eno od svojih žrtev.
Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
In exchange for his freedom, charming con artist Neal Caffrey provides his expertise to help straight-man FBI agent Peter Burke catch elusive white-collar criminals.
