A mad scientist, Dr. Aranya (Jackie Coogan), has created giant spiders in his Mexican lab in Zarpa Mesa to create a race of superwomen by injecting spiders with human pituitary growth hormones. Women develop miraculous regenerative powers, but men mutate into disfigured dwarves. Spiders grow to human size and intelligence.
Several people volunteer for a scientific experiment about mind-reading and memory, but the experiment goes horribly wrong.
Don Gregor, the son of famous plastic surgeon Dr. Boris Gregor, begins to hang around with young criminal Vic Brady and carry a gun. The pair attempt an armed holdup, and when things start to go wrong Gregor accidentally kills a night watchman. Fearing that Gregor plans to turn himself in, Brady kills him and blackmails Dr. Gregor into giving him a new face.
A man escorts a wagon load of Kentucky rifles through Indian territory and must find a way to get through without losing the rifles to the Indians. Unfortunately the Indians know about it, and give the occupants an ultimatum: either the rifles or their lives.
Ben Cooper, an old farmer, falls in love with the young blond hitchhiker Mari Lou. She falls in love with Ben Coopers money. But, will he have enough to make her happy?
The "boys" from Pine Ridge visit Europe and try to help a Yugoslavian ballerina find her American lover, become involved with French jewel thieves, and take on posh society in Monte Carlo.
